Abstract

Mini Review

Magnetic Properties of Reactive Oxygen Species and their Possible Role in Cancer Therapy

Boris Minaev*

Published: 19 August, 2024 | Volume 8 - Issue 1 | Pages: 048-053

Spin-depending internal magnetic interactions in oxygen are crucial for the chemistry and photobiology of this molecule. Photosynthesis, respiration, and many other life-supporting oxygen reactions are governed by enzymes that use fine magnetic forces to overcome the spin-forbidden character of all aerobic metabolism. Life on Earth occurs on the border between combustion and oxidative phosphorylation, and this balance is largely dependent on reactive oxygen species. ROS can cause apoptosis or cell necrosis, and ROS also controls homeostasis through numerous signaling functions. Until recently, biochemists had not paid attention to internal magnetic interactions that influence the chemical activity of such ROS as superoxide ion, singlet oxygen, peroxynitrite, and many others. The role of superoxide dismutase, the oldest enzyme on the Earth, which provides superoxide concentration control, stresses the importance of the O2-• species as the precursor of many other ROS. Spin-orbit coupling in O2-• and O2 species are the main internal magnetic interactions that could influence cancer growth and be connected with cancer therapy.

Read Full Article HTML DOI: 10.29328/journal.acst.1001044 Cite this Article Read Full Article PDF

References

    1. Mittler R. ROS are good. Trends Plant Sci. 2017;22(1):11-19. Available from: https://doi.org/10.1016/j.tplants.2016.08.002
    2. Minaev BF. Electronic mechanisms of molecular oxygen activation. Russ Chem Rev. 2007;76(11):988-1010. Available from: https://www.russchemrev.org/RCR3720pdf
    3. Wigner E, Witmer EE. Zeits. F. Physik. 1928;51:859-864.
    4. Minaev BF, Minaeva VA. Spin-dependent binding of dioxygen to heme and charge transfer mechanism of spin-orbit coupling enhancement. Ukr Biol Acta. 2008;2(1):56-64. Available from: https://www.bioorganica.org.ua/UBAdenovo/pubs_6_2_08/Minaev_2008_2.pdf
    5. Zadeh-Haghighi H, Simon C. Magnetic field effects in biology from the perspective of the radical pair mechanism. J R Soc Interface. 2022;19(193):20220325. Available from: https://doi.org/10.1098/rsif.2022.0325
    6. Prabhakar R, Siegbahn PE, Minaev BF. A theoretical study of the dioxygen activation by glucose oxidase and copper amine oxidase. Biochim Biophys Acta. 2003;1647(1-2):173-8. Available from: https://doi.org/10.1016/s1570-9639(03)00090-6
    7. Minaev BF. Magnetic torque in superoxide ion is the main driving force of dioxygen activation in aerobic life. Biomed J Sci Tech Res. 2021;38(4):121-131. Available from: http://dx.doi.org/10.26717/BJSTR.2021.38.006171
    8. Zheng J. Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review). Oncol Lett. 2012 Dec;4(6):1151-1157. Available from: https://doi.org/10.3892/ol.2012.928
    9. Krasnovsky AJ, Jr. Primary mechanisms of photoactivation of molecular oxygen. History of development and the modern status of research. Biochemistry (Moscow). 2007;72:1065-1080. Available from: https://doi.org/10.1134/s0006297907100057
    10. Lane N. Oxygen: The Molecule that Made the World. Oxford: Oxford University Press; 2002. p. 365. Available from: https://books.google.co.in/books/about/Oxygen.html?id=LXPrLcFdIPwC&redir_esc=y
    11. Zakharov II, Kudjukov KYu, Bondar VV, Tyupalo NF, Minaev BF. DFT-based thermodynamics of Fenton reactions rejects the ‘pure’ aquacomplex models. Comput Theor Chem. 2011;964:94-99. Available from: https://doi.org/10.1016/j.comptc.2010.12.004
    12. Sukhina MC. Spin-orbit coupling induced intersystem crossing in peroxynitrite. XXVI Ukrainian Conference of Young Scientists; Cherkasy, 2024;158-161.
    13. Minaev BF. Photochemistry and spectroscopy of singlet oxygen in solvents. Recent advances which support the old theory. Chem Chem Technol. 2016;10(4):519-530. Available from: http://dx.doi.org/10.23939/chcht10.04si.519
    14. Foot C. Mechanisms of photosensitized oxidation: There are several different types of photosensitized oxidation which may be important in biological systems. Science. 1968;162:963-970. Available from: https://doi.org/10.1126/science.162.3857.963
    15. Riebe J, Bädorf B, Löffelsender S, et al. Molecular folding governs switchable singlet oxygen photoproduction in porphyrin-decorated bistable rotaxanes. Commun Chem. 2024;7:171. Available from: https://www.nature.com/articles/s42004-024-01247-7
    16. Loboda O, Tunell I, Minaev BF, Ågren H. Theoretical study of triplet state properties of free-base porphin. Chem Phys. 2005;312(1-3):299-309. Available from: http://dx.doi.org/10.1016/j.chemphys.2004.11.041
    17. Yashchuk LB. Possible electronic mechanisms of generation and quenching of luminescence of singlet oxygen in the course of photodynamic therapy: ab initio study. Biopolym Cell. 2006;22(3):231-235.
    18. Minaev BF. Spin-orbit coupling of charge-transfer states and the mechanism for quenching singlet oxygen by amines. Theor Exp Chem. 1984;20(2):199-201. Available from: https://link.springer.com/article/10.1007/BF00592809
    19. Pang Y, Li C, Deng H, Sun Y. Recent advances in luminescent metallacycles/metallacages for biomedical imaging and cancer therapy. Dalton Trans. 2022;51:16428-16438. Available from: https://doi.org/10.1039/D2DT02766F
    20. Dos Santos AF, de Almeida DRQ, Terra LF, Baptista MS, Labriola L. Photodynamic therapy in cancer treatment - an update review. J Cancer Metastasis Treat. 2019;5:25. Available from: https://doi.org/10.20517/2394-4722.2018.83
    21. Land JE, Raith W. Fine structure of O2− measured by electron time-of-flight spectroscopy. Phys Rev Lett. 1973;30:349-352. Available from: https://doi.org/10.1103/PhysRevLett.30.349.2
    22. Panchenko OO, Minaev BF. Enzymatic spin-catalysis in flavin-containing oxidases and magnetic orientation of birds. Cherkasy Univ Bull Biol Sci Ser. 2018;1:114-120. Available from: https://bio-ejournal.cdu.edu.ua/article/view/2804
    23. Minaev BF, Lunell S, Kobzev GI. Collision-induced intensity of the b1Σg+−a1Δg transition in molecular oxygen: Model calculations for the collision complex O2+H2. Int J Quantum Chem. 1994;50(4):279-292. Available from: https://doi.org/10.1002/qua.560500405
    24. Minaev BF. Quantum-chemical investigation of the mechanisms of the photosensitization, luminescence, and quenching of singlet 1Δg oxygen in solutions. J Appl Spectrosc. 1985;42(5):518-523. Available from: https://link.springer.com/article/10.1007/BF00661398 

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