Abstract

Short Communication

Evaluation of long antigen exposition dendritic cell therapy (LANEX-DC®) in the adjuvant treatment of pancreatic cancer – results of a single center analysis

Frank Gansauge* and Bertram Poch

Published: 25 July, 2022 | Volume 6 - Issue 1 | Pages: 006-008

Introduction: Even after surgical resection and adjuvant chemotherapy in pancreatic cancer the 5-year disease-free survival times (DFS), as well as overall survival rates (OS), are still low and median survival times are below 2 years. Here we retrospectively analyzed the outcome of immunotherapy in the additional adjuvant treatment of pancreatic cancer with long antigen exposition dendritic cell therapy (LANEX-DC®) in 28 patients who were treated at our institution. 
Patients: Data were available from 28 patients. Dendritic cells (LAEX-DC®) were produced according to a recently published protocol.
Results: Therapy was well tolerated and no serious side effects were observed. The median disease-free survival times and the median survival times were 16,9 months and 29,4 months respectively. Five-year DFS and OS were 14,3% and 17,9%. 
Conclusion: We were able to show in a small cohort of patients that additional treatment with dendritic cells (LANEX-DC®) is highly effective and extends the median disease-free survival times as well as the median survival in the adjuvant treatment of pancreatic cancer, whereas the five-year overall survival still remains unsatisfactory.

Read Full Article HTML DOI: 10.29328/journal.acst.1001027 Cite this Article Read Full Article PDF

Keywords:

Pancreatic cancer; Dendritic cells; LANEX-DC®; Immunotherapy; Adjuvant

References

  1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019 Jan;69(1):7-34. doi: 10.3322/caac.21551. Epub 2019 Jan 8. PMID: 30620402.
  2. Groot VP, Rezaee N, Wu W, Cameron JL, Fishman EK, Hruban RH, Weiss MJ, Zheng L, Wolfgang CL, He J. Patterns, Timing, and Predictors of Recurrence Following Pancreatectomy for Pancreatic Ductal Adenocarcinoma. Ann Surg. 2018 May;267(5):936-945. doi: 10.1097/SLA.0000000000002234. PMID: 28338509.
  3. Oettle H, Neuhaus P, Hochhaus A, Hartmann JT, Gellert K, Ridwelski K, Niedergethmann M, Zülke C, Fahlke J, Arning MB, Sinn M, Hinke A, Riess H. Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial. JAMA. 2013 Oct 9;310(14):1473-81. doi: 10.1001/jama.2013.279201. PMID: 24104372.
  4. Conroy T, Hammel P, Hebbar M, Abdelghani MB, Wei AC. Canadian cancer trial group and the unicancer-GI-PRODIGE group. FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer. N Eng J Med. 2018; 379: 2395-2406.
  5. Palucka K, Banchereau J. Cancer immunotherapy via dendritic cells. Nat Rev Cancer. 2012 Mar 22;12(4):265-77. doi: 10.1038/nrc3258. PMID: 22437871; PMCID: PMC3433802.
  6. Sadeghzadeh M, Bornehdeli S, Mohahammadrezakhani H, Abolghasemi M, Poursaei E, Asadi M, Zafari V, Aghebati-Maleki L, Shanehbandi D. Dendritic cell therapy in cancer treatment; the state-of-the-art. Life Sci. 2020 Aug 1;254:117580. doi: 10.1016/j.lfs.2020.117580. Epub 2020 Mar 20. PMID: 32205087.
  7. Lepisto AJ, Moser AJ, Zeh H, Lee K, Bartlett D, McKolanis JR, Geller BA, Schmotzer A, Potter DP, Whiteside T, Finn OJ, Ramanathan RK. A phase I/II study of a MUC1 peptide pulsed autologous dendritic cell vaccine as adjuvant therapy in patients with resected pancreatic and biliary tumors. Cancer Ther. 2008;6(B):955-964. PMID: 19129927; PMCID: PMC2614325.
  8. Nagai K, Adachi T, Harada H, Eguchi S, Sugiyama H, Miyazaki Y. Dendritic Cell-based Immunotherapy Pulsed With Wilms Tumor 1 Peptide and Mucin 1 as an Adjuvant Therapy for Pancreatic Ductal Adenocarcinoma After Curative Resection: A Phase I/IIa Clinical Trial. Anticancer Res. 2020 Oct;40(10):5765-5776. doi: 10.21873/anticanres.14593. PMID: 32988904.
  9. Gansauge F, Poch B, Kleef R, Schwarz M. Effectivity of long antigen exposition dendritic cell therapy (LANEXDC®) in the palliative treatment of pancreatic cancer. Curr Med Chem. 2013;20(38):4827-35. doi: 10.2174/09298673113206660290. PMID: 24083599.
  10. Gansauge F, Poch B. Effectivity of Long Antigen Exposition Dendritic Cell Therapy (LANEX-DC®) in the Adjuvant Treatment of Gastric Cancer. Clin Oncol. 2022; 7: 1929-31.
  11. Maeda S, Unno M, Yu J. Adjuvant and neoadjuvant therapy for pancreatic cancer. J Pancreatol. 2019; 2: 100-106.

Figures:

Figure 1

Figure 1

Figure 1

Figure 2

Similar Articles

Recently Viewed

  • Synthesis of Carbon Nano Fiber from Organic Waste and Activation of its Surface Area
    Himanshu Narayan*, Brijesh Gaud, Amrita Singh and Sandesh Jaybhaye Himanshu Narayan*,Brijesh Gaud,Amrita Singh,Sandesh Jaybhaye. Synthesis of Carbon Nano Fiber from Organic Waste and Activation of its Surface Area. Int J Phys Res Appl. 2019: doi: 10.29328/journal.ijpra.1001017; 2: 056-059
  • Obesity Surgery in Spain
    Aniceto Baltasar* Aniceto Baltasar*. Obesity Surgery in Spain. New Insights Obes Gene Beyond. 2020: doi: 10.29328/journal.niogb.1001013; 4: 013-021
  • Tamsulosin and Dementia in old age: Is there any relationship?
    Irami Araújo-Filho*, Rebecca Renata Lapenda do Monte, Karina de Andrade Vidal Costa and Amália Cinthia Meneses Rêgo Irami Araújo-Filho*,Rebecca Renata Lapenda do Monte,Karina de Andrade Vidal Costa,Amália Cinthia Meneses Rêgo. Tamsulosin and Dementia in old age: Is there any relationship?. J Neurosci Neurol Disord. 2019: doi: 10.29328/journal.jnnd.1001025; 3: 145-147
  • Case Report: Intussusception in an Infant with Respiratory Syncytial Virus (RSV) Infection and Post-Operative Wound Dehiscence
    Lamin Makalo*, Orlianys Ruiz Perez, Benjamin Martin, Cherno S Jallow, Momodou Lamin Jobarteh, Alagie Baldeh, Abdul Malik Fye, Fatoumatta Jitteh and Isatou Bah Lamin Makalo*,Orlianys Ruiz Perez,Benjamin Martin,Cherno S Jallow,Momodou Lamin Jobarteh,Alagie Baldeh,Abdul Malik Fye,Fatoumatta Jitteh,Isatou Bah. Case Report: Intussusception in an Infant with Respiratory Syncytial Virus (RSV) Infection and Post-Operative Wound Dehiscence. J Community Med Health Solut. 2025: doi: 10.29328/journal.jcmhs.1001051; 6: 001-004
  • The prevalence and risk factors of chronic kidney disease among type 2 diabetes mellitus follow-up patients at Debre Berhan Referral Hospital, Central Ethiopia
    Getaneh Baye Mulu, Worku Misganew Kebede, Fetene Nigussie Tarekegn, Abayneh Shewangzaw Engida, Migbaru Endawoke Tiruye, Mulat Mossie Menalu, Yalew Mossie, Wubshet Teshome and Bantalem Tilaye Atinafu* Getaneh Baye Mulu,Worku Misganew Kebede,Fetene Nigussie Tarekegn,Abayneh Shewangzaw Engida,Migbaru Endawoke Tiruye,Mulat Mossie Menalu,Yalew Mossie,Wubshet Teshome,Bantalem Tilaye Atinafu*. The prevalence and risk factors of chronic kidney disease among type 2 diabetes mellitus follow-up patients at Debre Berhan Referral Hospital, Central Ethiopia. J Clini Nephrol. 2023: doi: 10.29328/journal.jcn.1001104; 7: 025-031

Read More

Most Viewed

Read More

Help ?