Abstract

Research Article

Vaginal embryonal rhabdomyosarcoma in young woman: A case report and literature review

Issam Lalya*, Sana Laatitioui, Abdelhamid E, Omrani, Mouna Khouchani and Ismail Essadi

Published: 25 May, 2020 | Volume 4 - Issue 1 | Pages: 034-037

Rhabdomyosarcomas are the most common soft tissue tumors of childhood. They are characterized by their poor prognosis. Vaginal location is very rare after puberty and exceptional in the post menopause. Treatment is based on several therapeutic measures combining neoadjuvant chemotherapy followed by surgery and/or external beam radiation therapy. We report herein the case of a 25 years-old woman, presented with vaginal embryonal RMS revealed by metrorrhagia and pelvic pain. The diagnosis was confirmed by biopsy and histopathological study. Pre-treatment workup was negative for metastatic disease. She has received chemotherapy based on vincristine, doxorubicin, and cyclophosphamide. The clinical evolution was marked by improvement of symptoms, unfortunately the patient died following febrile neutropenia after the third cycle of chemotherapy.

Read Full Article HTML DOI: 10.29328/journal.acst.1001020 Cite this Article Read Full Article PDF

Keywords:

Embryonal rhabdomyosarcoma; Vagina; Young woman

References

  1. Ries LAGHD, Krapcho M, Mariotto A, Miller BA, Feuer EJ, et al. SEER Cancer Statistics Review, 1975–2003. Bethesda: National Cancer Institute; 2006.
  2. Baiocchi G, Faloppa CC, de Toledo Osorio CA, Kumagai LY, Fukazawa EM, et al. Embryonal rhabdomyosarcoma of the uterine cervix in a 47-year-old woman. J Obstet Gynaecol Res. 2011; 37: 940–946.
  3. Chauhan RS, Singh DK, Guha B, Kumar> I, Verma A. Multimodality imaging of vaginal rhabdomyosarcoma Genitourinary .Indian J Radiol Imaging. 2017; 27: 148–151. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510311/
  4. Ditto A, Martinelli F, Carcangiu M, Solima E, de Carrillo KJA, et al. Embryonal rhabdomyosarcoma of the uterine cervix in adults: a case report and literature review. J Low Genit Tract Dis. 2013; 17: e12‐e17. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23903199
  5. Behtash N, Mousavi A, Tehranian A, Khanafshar N, Hanjani P. Embryonal rhabdomyosarcoma of the uterine cervix: Case report and review of the literature. Gynecologic Oncology. 2003; 91: 452-455. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/14599884
  6. Dehner LP, Jarzembowski JA, Hill DA. Embryonal rhabdomyosarcoma of the uterine cervix: a report of 14 cases and a discussion of its unusual clinicopathological associations. Mod Pathol. 2012; 25: 602–614. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22157934
  7. Kriseman ML, Wang WL, Sullinger J, Schmeler KM, Ramirez PT, et al. Rhabdomyosarcoma of the cervix in adult women and younger patients. Gynecol Oncol. 2012; 126: 351–356. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939703/
  8. Saâdi I, Errihani H, Haddadi K, Amaoui B, Benjaafar B, et al. Rhabdomyosarcome botryoïde du col utérin: à propos d’un cas Sarcoma botryoïde of the uterine cervix. Canc/Radiother. 2002; 6: 363–365.
  9. Van Rijn R, Wilde JCH, Bras J, Oldenburger F, McHugh K, et al. Imaging findings in noncraniofacial childhood rhabdomyosarcoma. Pediatr Radiol. 2008; 38: 617‑ PubMed: https://www.ncbi.nlm.nih.gov/pubmed/18324394
  10. Sanders MA, Gordinier M, Talwalkar SS, Moore GD. Embryonal rhabdomyosarcoma of the uterine cervix in a 41-year-old woman treated with radical hysterectomy and adjuvant chemotherapy. Gynecol Oncol. 2008; 111: 561–563. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092352/
  11. Fletcher C, Bridge J, Hogendroom P, Mertrens F. WHO Classification of Tumours of Soft Tissue and Bone. Lyon: IARC; 2013.
  12. Andrassy RJ, Wiener ES, Raney RB, Hays DM, Arndt CA, et al. Progress in the Surgical Management of Vaginal Rhabdomyosarcoma: A 25-year Review From the Intergroup Rhabdomyosarcoma Study Group. J Pediatr Surg. 1999; 34: 731-734. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/10359173
  13. Copeland LJ, Sneige N, Stringer CA, Gershenson DM, Saul PB, et al. Alveolar rhabdomyosarcoma of the female genitalia. Cancer. 1985; 56: 849-855. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/4016676
  14. Kriseman ML, Wang WL, Sullinger J, et al. Rhabdomyosarcoma of the cervix in adult women and younger patients. Gynecol Oncol. 2012; 126: 351‐356. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939703/
  15. Ojwang SB, Rana F, Sayed S, Aruasa WK. Embryonal rhabdomyosarcoma with uterine inversion: Case report. East Afr Med J. 2006; 83: 110‐113. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16771108
  16. Kim DW, Shin JH, Lee HJ, Hong YO, Joo JE, et al. Spindle cell rhabdomyosacoma of uterus: A case study. Korean J Pathol. 2013; 47: 388‐391. PubMed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759640/
  17. Hemida R, Goda H, Abdel‐Hady el‐S, El‐Ashry R. Embryonal rhabdomyosarcoma of the female genital tract: 5 years’ experience. J Exp Ther Oncol. 2012; 10: 135‐137. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23350353
  18. Kirsch CH, Goodman M, Esiashvili N. Outcome of female pediatric patients diagnosed with genital tract rhabdomyosarcoma based on analysis of cases registered in SEER database between 1973 and 2006. Am J Clin Oncol. 2014; 37: 47‐50. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23111355
  19. Fukunaga M. Pure alveolar rhabdomyosarcoma of the uterine corpus. Pathol Int. 2011; 61: 377‐381. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21615615
  20. Chmaj‐Wierzchowska K, Wierzchowski M, Szymanowski K, Czerniak T, Mróz M, et al. Pleomorphic rhabdomyosarcoma of the uterine corpus ‐ A case report. Ginekol Pol. 2010; 81: 541‐543. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20825058
  21. Adams BN, Brandt JS, Loukeris K, Holcomb K. Embryonal rhabdomyosarcoma of the cervix and appendiceal carcinoid tumor. Obstet Gynecol. 2011; 117: 482‐484. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21252797
  22. Nasioudis D, Alevizakos M, Chapman-Davis E, Witkin SS, Holcomb K. Rhabdomyosarcoma of the lower female genital tract: an analysis of 144 cases. Arch Gynecol Obstet. 2017; 296: 327‐334. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28634755

Figures:

Figure 1

Figure 1

Similar Articles

Recently Viewed

Read More

Most Viewed

Read More

Help ?